Non-profit organizations, just as their name suggests, are organizations whose main goal is not to gain profit but to achieve some sort of benefit for society. The management of non-profit organizations is engaged in studying all such organizations within public and civil sector. Nonprofit organizations are agents of social change, aimed to serve public and the citizens, they have to meet all the needs that are not met by the state and the market, so their role in society is very important. In order for them to be successful and achieve high quality results they need professional and responsible leadership, and a serious approach to planning, managing, organizing and controlling their activities. So, they need effective management to fulfill the primary purpose or to achieve social change. In addition to efficient management, it is necessary to fully understand the non-profit sector and its specifics, and cooperation with other sectors is also needed so that the overall society functions better. When talking about nonprofit organizations, it is important to mention the Quadruple Helix model, an approach in which governments, industry, academic community, and civil society work together to create future changes that are beyond the scope of what individual organizations or any individuals can do. Nowadays, people increasingly recognize the importance of the non-profit sector and want to participate in its work. How to measure the performance of nonprofit organizations is one of the key issues and problems that nonprofit management faces. The environment in which nonprofit organizations operate is complex and it is difficult to determine the interests and influence of all stakeholders. The goal of nonprofit organizations is to accomplish a mission, the social impacts that an organization achieves primarily do not have quantitative traits but are qualitative in their nature, which makes it difficult compare non-profit organisations. Great challenges for nonprofit management are also raising the financial resources needed to operate the organization and attracting high quality human resources, employees and volunteers, and also motivating them.