Omnipresence of informatics is an unbeatable fact which significantly influences modern economy. With the changes of human knowledge, coming with the growth of population, the needs of humanity changed, to get longer lasting activities faster and simplified, as to have the quicker access to desired information. This thesis will analyze the problematics of using Excel spreadsheet in business organizations and institutions which operate with certain amount of data, and want to have fast and accurate business reports. Excel is a program meant for usage at personal computers, developed from global brand in a world of computing and information, Microsoft. In a nutshell, the program's purpose is in simplified calculations and managing large amount of numeric and non-numeric data. Here comes to a main point interweaving of disciplines and sciences who doesn't have some common points at the first view, like informatics, maths, statistics and different fields of economy. Excel is an advanced spreadsheet which contains installed mathematical functions in advance to improve the business, or for the physical persons whose want to have insight into movement of their household, are just some of examples. In the theoretical part of the thesis, we give a short overview of history of Excel and development of its possibilities, while in the practical part we provide examples of usage a number of Excel functions in processing business data.