Technical and technological development in the history significantly affected, not only a creation of new professions which are the consequence of development, but also influenced the changes in society. The main focus of this Thesis is on the impact that development has on creation of new professions and thus does not consider the other segments in which this development has also had an impact. The main subject of this Thesis are professions gained through Higher education. The analysis of existing and future professions and the current situation in the labor market are discussed. There is no systematic approach in managing qualifications gained through Croatian Higher education system and the needs of the labor market and the economy are not currently met. For that reason a Unique model for managing supply and demand of Higher education qualifications in the Republic of Croatia, was created. The Thesis is structured in five main chapters including the Introduction chapter that introduces the reader to a topic that is discussed. The need of research and research problem is described. Goals and tasks are set. The main and auxiliary hypotheses, scientific methods and techniques applied in the Thesis are described. Scientific and practical contribution of the Thesis is shown. The main used sources and the Thesis structure are described. The second chapter presents technical, technological and scientific development through historical technological revolutions. Technological and scientific development in the year period 1990 to 2013 is shown and presented occupations that were created during that period. The third chapter very detailed shows the Higher education system in Republic of Croatia where the definitions of basic terms are given, described the system of Higher education, presented the Croatian studies, professions and qualifications earned after graduation. The fourth chapter contains the results and the analysis of results of research of needs for Higher education qualifications. It is explained the research methodology and shown the needs for qualifications by sector. A comparation of the output of qualifications with the needs for qualifications is made. The guidelines for the development of Higher education qualifications in the near future, are given. The second part of chapter four is consisted of forecasting the needs for qualifications through the prediction of science and technology development in the future. The global future needs are shown, too. In this chapter are also presented some of the future occupations till 2030. As a Case Study, the projection of implementing Palliative Care in Republic of Croatia, was done. At the end of the chapter a Unique model for managing supply and demand of Higher education qualifications in the Republic of Croatia, was described and graphically shown. The fifth and ending chapter is a Conclusion which lists the results based on set tasks, goals and hypotheses. Recommendations for further researches are given.