The demographic and economic stability of the counties of Slavonia, Baranja and Srijem (related to: Virovitica-Podravska, Požega-Slavonia, Brod-Posavina, Osijek-Baranja and Vukovar-Srijem) requires an integrated approach involving detailed analysis and the application of various policies and strategies. These regions have traditionally faced challenges such as out-migration, low birth rates and economic stagnation. Therefore, it is crucial to focus on finding sustainable solutions that will enable the long-term stability of this part of the Republic of Croatia. The decline of demographic capital in Slavonia, Baranja and Srijem has complex and profound consequences for the economy and overall sustainability of these areas. The emigration of young people, the aging of the population and the low fertility rate are the main demographic challenges, while the economic consequences are manifested in uneven economic development, high unemployment and the loss of labor. By analyzing existing demographic and economic data, this paper identifies the key factors contributing to the current situation and proposes guidelines that can support demographic renewal and economic development. This includes proposals such as improving infrastructure, supporting small and medium-sized enterprises, implementing specific demographic measures and the effective use of EU funds. Particular attention will be paid to improving the education system in line with the needs of the labor market, developing rural tourism and agritourism as economic opportunities and promoting regional cooperation. By implementing integrated policies and measures, Slavonia, Baranja and Srijem have the potential to transform into sustainable and prosperous regions that will offer a high quality of life to their inhabitants and attract investment. Investments in these regions will not only contribute to their local development, but will also have a positive impact on the entire economy and society of the Republic of Croatia.